Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 261 (1), 32-43

Active Sugar Transport in Health and Disease

Affiliations
Review

Active Sugar Transport in Health and Disease

E M Wright et al. J Intern Med.

Abstract

Secondary active glucose transport occurs by at least four members of the SLC5 gene family. This review considers the structure and function of two premier members, SGLT1 and SGLT2, and their role in intestinal glucose absorption and renal glucose reabsorption. Genetics disorders of SGLTs include Glucose-Galactose Malabsorption, and Familial Renal Glucosuria. SGLT1 plays a central role in Oral Rehydration Therapy used so effectively to treat secretory diarrhoea such as cholera. Increasing attention is being focused on SGLTs as drug targets for the therapy of diabetes.

Similar articles

See all similar articles

Cited by 138 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources

Feedback