Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 261 (1), 32-43

Active Sugar Transport in Health and Disease


Active Sugar Transport in Health and Disease

E M Wright et al. J Intern Med.


Secondary active glucose transport occurs by at least four members of the SLC5 gene family. This review considers the structure and function of two premier members, SGLT1 and SGLT2, and their role in intestinal glucose absorption and renal glucose reabsorption. Genetics disorders of SGLTs include Glucose-Galactose Malabsorption, and Familial Renal Glucosuria. SGLT1 plays a central role in Oral Rehydration Therapy used so effectively to treat secretory diarrhoea such as cholera. Increasing attention is being focused on SGLTs as drug targets for the therapy of diabetes.

Similar articles

  • Novel and Unexpected Functions of SGLTs
    EM Wright et al. Physiology (Bethesda) 32 (6), 435-443. PMID 29021363. - Review
    It has been 30 years since the intestinal sodium glucose cotransporter SGLT1 was cloned, and, in the intervening years, there have been many advances that have influenced …
  • Glucose Control by the Kidney: An Emerging Target in Diabetes
    O Marsenic. Am J Kidney Dis 53 (5), 875-83. PMID 19324482. - Review
    The full significance of the kidney's role in glucose homeostasis is now well recognized. For example, it is now known that renal gluconeogenesis contributes substantiall …
  • Functional Characterization of Mouse Sodium/Glucose Transporter Type 3b
    O Aljure et al. Am J Physiol Cell Physiol 299 (1), C58-65. PMID 20392930.
    Despite belonging to a family of sugar cotransporters, human sodium/glucose transporter type 3 (hSGLT3) does not transport sugar, but it depolarizes the cell in the prese …
  • Mouse SGLT3a Generates Proton-Activated Currents but Does Not Transport Sugar
    S Barcelona et al. Am J Physiol Cell Physiol 302 (8), C1073-82. PMID 22301059.
    Sodium-glucose cotransporters (SGLTs) are secondary active transporters belonging to the SLC5 gene family. SGLT1, a well-characterized member of this family, electrogenic …
  • Molecular Basis for Glucose-Galactose Malabsorption
    EM Wright et al. Cell Biochem Biophys 36 (2-3), 115-21. PMID 12139397. - Review
    Glucose-galactose malabsorption (GGM) is an autosomal recessive disease that presents in newborn infants as a life-threatening diarrhea. The diarrhea ceases within 1 h of …
See all similar articles

Cited by 135 PubMed Central articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources