Prevention of recurrent haemorrhage

Best Pract Res Clin Gastroenterol. 2007;21(1):43-53. doi: 10.1016/j.bpg.2006.07.003.

Abstract

Patients who survive a first bleeding episode of oesophageal varices have a high risk of rebleeding, which is associated with a high mortality rate. Prevention of a recurrent haemorrhage is therefore recommended. Patients who were not on a primary prophylaxis should be treated with non-selective beta-adrenoceptor antagonists, endoscopic band ligation or both. If beta-blockers are not tolerated or are contraindicated, patients should be treated with endoscopic band ligation. If these preventive strategies fail, transjugular intrahepatic portosystemic shunt (covered) or a small-diameter surgical shunt is indicated.

Publication types

  • Review

MeSH terms

  • Adrenergic beta-Antagonists / therapeutic use
  • Esophageal and Gastric Varices / complications
  • Esophageal and Gastric Varices / diagnosis*
  • Gastrointestinal Hemorrhage / etiology
  • Gastrointestinal Hemorrhage / prevention & control*
  • Hemostasis, Endoscopic
  • Humans
  • Hypertension, Portal / complications
  • Hypertension, Portal / diagnosis*
  • Sclerotherapy / methods
  • Secondary Prevention
  • Vasodilator Agents / therapeutic use

Substances

  • Adrenergic beta-Antagonists
  • Vasodilator Agents