Vitamin D in the treatment of pulmonary tuberculosis

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):793-8. doi: 10.1016/j.jsbmb.2006.12.052. Epub 2007 Jan 12.


Vitamin D was used to treat tuberculosis in the pre-antibiotic era. New insights into the immunomodulatory properties of 1alpha,25-dihydroxy-vitamin D have rekindled interest in vitamin D as an adjunct to antituberculous therapy. We describe the historical use of vitamin D in tuberculosis treatment; discuss the mechanisms by which it may modulate host response to infection with Mycobacterium tuberculosis; and review three clinical trials and ten case series in which vitamin D has been used in the treatment of pulmonary tuberculosis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Dose-Response Relationship, Drug
  • Humans
  • Macrophages / drug effects
  • Macrophages / metabolism
  • Tuberculosis, Pulmonary / drug therapy*
  • Tuberculosis, Pulmonary / metabolism
  • Tuberculosis, Pulmonary / microbiology*
  • Tuberculosis, Pulmonary / pathology
  • Vitamin D / adverse effects
  • Vitamin D / biosynthesis
  • Vitamin D / therapeutic use*


  • Vitamin D