Thinking within the D box: initial identification of Cdh1-APC substrates in the nervous system

Mol Cell Neurosci. 2007 Mar;34(3):281-7. doi: 10.1016/j.mcn.2006.11.019. Epub 2007 Jan 12.


The anaphase-promoting complex (APC) has a well-established role in cell cycle control, but recent exciting evidence has uncovered unexpected neurobiological functions for this complex E3 ubiquitin ligase. With its co-activator Cdh1, APC's effects upon the nervous system range from regulation of axon growth and patterning to development of synapses to neuronal survival. The Cdh1-APC substrates that control these biological processes in neurons are just beginning to be identified. These findings may offer a glimpse of the wide spectrum of neural activities that are orchestrated by Cdh1-APC.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Axons / metabolism
  • Cadherins / metabolism*
  • Cell Cycle / physiology
  • Cell Death / physiology
  • Humans
  • Nervous System / cytology
  • Nervous System / metabolism*
  • Synapses / physiology
  • Ubiquitin-Protein Ligase Complexes / metabolism*


  • Cadherins
  • Ubiquitin-Protein Ligase Complexes
  • Anaphase-Promoting Complex-Cyclosome