Risk factors for ocular complications and poor visual acuity at presentation among patients with uveitis associated with juvenile idiopathic arthritis

Am J Ophthalmol. 2007 Apr;143(4):647-55. doi: 10.1016/j.ajo.2006.11.025. Epub 2006 Dec 20.


Purpose: To describe the frequencies of and risk factors for ocular complications and poor visual acuity at presentation in a cohort of patients with juvenile idiopathic arthritis (JIA)-associated uveitis.

Design: Cross-sectional study.

Methods: setting: Single-center, academic practice. study population: Seventy-five patients with JIA-associated uveitis were evaluated between July 1984 and August 2005. observation procedures: Data on patients diagnosed with JIA-associated uveitis were entered retrospectively into a database and analyzed. outcome measures: Visual acuity of 20/50 or worse or 20/200 or worse, and presence of ocular complications (including cataract, posterior synechiae, band keratopathy, elevated intraocular pressure, hypotony, macular edema, and epiretinal membrane) at presentation.

Results: At presentation, ocular complications were seen in 67% of eyes affected by JIA-associated uveitis. Presence of > or =1+ anterior chamber flare, a positive antinuclear antibody (ANA), and a shorter duration between the diagnosis of arthritis and uveitis were significantly associated with the presence of ocular complication. The frequencies of 20/50 or worse and of 20/200 or worse visual acuities at presentation in affected eyes were 36% and 24%, respectively. The presence of > or =1+ anterior chamber flare and a history of intraocular surgery before presentation were significantly associated with 20/50 or worse and 20/200 or worse vision. Presence of posterior synechiae also was associated with 20/200 or worse vision at presentation. The main causes of poor vision at presentation for affected eyes and better-seeing eyes were cataract, band keratopathy within the visual axis, and glaucoma.

Conclusions: Ocular complications and poor vision at presentation were common in our patients with JIA-related uveitis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Antinuclear / blood
  • Arthritis, Juvenile / complications*
  • Arthritis, Juvenile / diagnosis
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Eye Diseases / etiology*
  • Female
  • Humans
  • Infant
  • Male
  • Retrospective Studies
  • Risk Factors
  • Uveitis, Anterior / complications*
  • Uveitis, Anterior / diagnosis
  • Vision Disorders / etiology
  • Visual Acuity*


  • Antibodies, Antinuclear