Relationship of cerebral blood flow and central visual function in primary open-angle glaucoma

J Glaucoma. 2007 Jan;16(1):159-63. doi: 10.1097/01.ijg.0000212290.08540.93.


Purpose: To investigate the relations between middle cerebral artery (MCA) blood flow velocities and central visual function measured by foveal cone electroretinograms (ERG) and visual field.

Methods: Fifteen primary open-angle glaucoma patients were recruited. The eye with the more severe visual field defect (full threshold 24-2) and/or optic disc damage was chosen. Measurements included brachial arterial pressure, heart rate, visual acuity (logMAR), contrast sensitivity (CSV-1000), central visual field (Humphrey SITA 10-2), foveal cone ERG, and transcranial Doppler. Pearson correlation coefficients were estimated to assess the strength of the linear relationship between the MCA flow velocity and the other measured parameters.

Results: Visual field was successfully completed in 12 eyes. We were unable to obtain ERG responses and MCA velocity readings for 1 patient. A significant correlation was observed between MCA mean flow velocity and focal cone ERG amplitude [r=0.69, n=13, confidence interval (CI) 0.22, 0.90, P=0.009], but correlation between mean foveal cone ERG implicit time and middle cerebral was not statistically significant (r=0.011, n=13, CI 0.47, 0.63). A significant correlation was also observed between MCA mean flow velocity and mean sensitivity (r=0.76, n=12, CI 0.32, 0.93, P=0.005), and mean defect (r=0.73, n=12, CI 0.28, 0.92, P=0.007) of the central visual field, logMAR visual acuity (r=0.57, n=14, CI 0.05, 0.84, P=0.036), and contrast sensitivity (r=0.61, n=13, CI 0.09, 0.87, P=0.027).

Conclusions: Our findings suggest that in certain primary open-angle glaucoma patients diminished central visual function may be one manifestation of widespread cerebrovascular insufficiency.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Flow Velocity
  • Blood Pressure
  • Brain / blood supply*
  • Cerebral Arteries / physiology*
  • Cerebrovascular Circulation / physiology*
  • Contrast Sensitivity / physiology
  • Electroretinography
  • Female
  • Glaucoma, Open-Angle / physiopathology*
  • Heart Rate / physiology
  • Humans
  • Intraocular Pressure
  • Laser-Doppler Flowmetry
  • Male
  • Middle Aged
  • Optic Nerve Diseases / physiopathology
  • Retina / physiology
  • Visual Acuity / physiology*
  • Visual Fields / physiology*