Radiosurgery for spinal metastases: clinical experience in 500 cases from a single institution

Spine (Phila Pa 1976). 2007 Jan 15;32(2):193-9. doi: 10.1097/01.brs.0000251863.76595.a2.


Study design: A prospective nonrandomized, longitudinal cohort study.

Objective: To evaluate the clinical outcomes of single-fraction radiosurgery as part of the management of metastatic spine tumors.

Summary of background data: The role of stereotactic radiosurgery for the treatment of spinal lesions has previously been limited by the availability of effective target immobilization and target tracking devices. Large clinical experience with spinal radiosurgery to properly assess clinical experience has previously been limited.

Methods: A cohort of 500 cases of spinal metastases underwent radiosurgery. Ages ranged from 18 to 85 years (mean 56). Lesion location included 73 cervical, 212 thoracic, 112 lumbar, and 103 sacral.

Results: The maximum intratumoral dose ranged from 12.5 to 25 Gy (mean 20). Tumor volume ranged from 0.20 to 264 mL (mean 46). Long-term pain improvement occurred in 290 of 336 cases (86%). Long-term tumor control was demonstrated in 90% of lesions treated with radiosurgery as a primary treatment modality and in 88% of lesions treated for radiographic tumor progression. Twenty-seven of 32 cases (84%) with a progressive neurologic deficit before treatment experienced at least some clinical improvement.

Conclusions: The results indicate the potential of radiosurgery in the treatment of patients with spinal metastases, especially those with solitary sites of spine involvement, to improve long-term palliation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Disease Progression
  • Dose-Response Relationship, Radiation
  • Female
  • Humans
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Nervous System Diseases / etiology
  • Nervous System Diseases / physiopathology
  • Pain, Postoperative / physiopathology
  • Palliative Care
  • Postoperative Period
  • Prospective Studies
  • Radiography
  • Radiosurgery*
  • Spinal Neoplasms / complications
  • Spinal Neoplasms / diagnostic imaging
  • Spinal Neoplasms / secondary*
  • Spinal Neoplasms / surgery*
  • Treatment Outcome