Abstract
(+)-Eudesmin [4,8-bis(3,4-dimethoxyphenyl)-3,7-dioxabicyclo[3.3.0]octane] was isolated from the stem bark of Magnolia kobus DC. var. borealis Sarg. and found to have neuritogenic activity. 50 microM (+)-eudesmin induced neurite outgrowth and enhanced nerve growth factor (NGF)-mediated neurite outgrowth from PC12 cells. At this concentration, (+)-eudesmin also enhanced NGF-induced neurite-bearing activity and this activity was partially blocked by various protein kinase inhibitors. These included PD98059, a mitogen-activated protein kinase (MAPK) kinase inhibitor. GF109203X, a protein kinase C (PKC) inhibitor and H89, a protein kinase A (PKA) inhibitor. These results suggest that (+)-eudesmin can induce neurite outgrowth from PC12 cells by stimulating up-stream MAPK, PKC and PKA pathways.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Flavonoids / pharmacology
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Furans / antagonists & inhibitors
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Furans / isolation & purification
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Furans / pharmacology*
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Humans
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Indoles / pharmacology
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Isoquinolines / pharmacology
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Lignans / antagonists & inhibitors
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Lignans / isolation & purification
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Lignans / pharmacology*
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Magnetic Resonance Spectroscopy
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Magnolia / chemistry*
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Maleimides / pharmacology
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Neurites / drug effects*
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PC12 Cells
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Plant Bark / chemistry*
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Protein Kinase Inhibitors / pharmacology
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Rats
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Sulfonamides / pharmacology
Substances
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Flavonoids
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Furans
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Indoles
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Isoquinolines
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Lignans
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Maleimides
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Protein Kinase Inhibitors
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Sulfonamides
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eudesmin
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bisindolylmaleimide I
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N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide
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2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one