Angioedema is characterized by transient, episodic, nonpruritic, nonpitting and well-defined edema that involves the subcutaneous or submucosal tissue, and most commonly develops in the head and neck region. Angioedema is caused by extravasation of plasma into the interstitial space of the affected tissue. We describe a six-year-old boy who developed oral and penile angioedema subsequent to the ingestion of peanuts.