Celiac disease presenting with motor neuropathy: effect of gluten free-diet

Muscle Nerve. 2007 May;35(5):675-7. doi: 10.1002/mus.20727.


Celiac disease is a rare cause of neuropathy that most commonly presents with symmetric distal sensory disturbances. We describe two patients with celiac disease in whom neuropathy presented unusually with progressive weakness of the limbs. In both patients a gluten-free diet induced a significant improvement of muscle strength and neurophysiological abnormalities, suggesting a direct pathogenetic role of sensitivity to gluten. Celiac disease should be considered in patients with idiopathic neuropathy even when gastrointestinal symptoms are absent.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Celiac Disease / complications*
  • Celiac Disease / diagnosis*
  • Celiac Disease / diet therapy
  • Diet
  • Female
  • Glutens / administration & dosage
  • Humans
  • Middle Aged
  • Motor Neuron Disease / diagnosis*
  • Motor Neuron Disease / diet therapy
  • Motor Neuron Disease / etiology*


  • Glutens