NF-kappa B as a target for cancer therapy

Expert Opin Ther Targets. 2007 Feb;11(2):133-44. doi: 10.1517/14728222.11.2.133.


NF-kappaB transcription factors and the signaling pathways that activate them play a critical role in cancer development, progression and therapy, and recently have become a focal point for intense drug discovery and development efforts. This article presents a critical review on the different types of inhibitors targeting the NF-kappaB pathway at several stages.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / chemistry
  • Drug Delivery Systems / methods*
  • Humans
  • NF-kappa B / antagonists & inhibitors*
  • NF-kappa B / metabolism*
  • Neoplasms / drug therapy
  • Neoplasms / metabolism*
  • Signal Transduction / drug effects
  • Signal Transduction / physiology


  • Antineoplastic Agents
  • NF-kappa B