The 25-hydroxyvitamin D threshold for better health

J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):614-9. doi: 10.1016/j.jsbmb.2006.12.016. Epub 2007 Jan 16.


Available data supporting a target serum level of at least 75 nmol/l 25-hydroxyvitamin D (25-OHD) include studies on bone mineral density (bmd), fracture prevention, lower extremity function, and cancer prevention. Given the high cost and disability from falls, fractures, and cancer treatment a shared threshold for 25-OHD has significant public health implications, especially so, if a large part of the population is below this threshold. This article summarizes available evidence supporting the 75 nmol/l threshold, reviews adherence to Vitamin D treatment in fracture trials in regard to achieved anti-fracture efficacy, and finally discusses current recommendations for Vitamin D intake.

MeSH terms

  • Bone Density / drug effects
  • Fractures, Bone
  • Health*
  • Humans
  • Lower Extremity / pathology
  • Neoplasms / metabolism
  • Neoplasms / mortality
  • Risk Factors
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Vitamin D / pharmacology


  • Vitamin D
  • 25-hydroxyvitamin D