Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility

Nat Rev Genet. 2007 Feb;8(2):126-38. doi: 10.1038/nrg2042.


Signalling through Frizzled (Fz)/planar cell polarity (PCP) is a conserved mechanism that polarizes cells along specific axes in a tissue. Genetic screens in Drosophila melanogaster pioneered the discovery of core PCP factors, which regulate the orientation of hairs on wings and facets in eyes. Recent genetic evidence shows that the Fz/PCP pathway is conserved in vertebrates and is crucial for disparate processes as gastrulation and sensory cell orientation. Fz/PCP signalling depends on complex interactions between core components, leading to their asymmetric distribution and ultimately polarized activity in a cell. Whereas several mechanistic aspects of PCP have been uncovered, the global coordination of this polarization remains debated.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Body Patterning / genetics*
  • Cell Movement / physiology*
  • Cell Polarity / physiology*
  • Conserved Sequence / genetics
  • Drosophila Proteins / genetics*
  • Drosophila melanogaster / genetics*
  • Drosophila melanogaster / physiology
  • Evolution, Molecular
  • Frizzled Receptors / genetics*
  • Gene Expression Regulation / genetics*
  • Receptors, G-Protein-Coupled / genetics*
  • Signal Transduction / genetics*
  • Signal Transduction / physiology
  • Vertebrates / genetics*
  • Vertebrates / physiology


  • Drosophila Proteins
  • Frizzled Receptors
  • Receptors, G-Protein-Coupled
  • fz protein, Drosophila