ELAVL4, PARK10, and the Celts

Mov Disord. 2007 Mar 15;22(4):585-7. doi: 10.1002/mds.21336.

Abstract

Genetic variability in ELAVL4 located in the PARK10 locus was recently associated with age-at-onset (AAO) in a series of Parkinson's disease (PD) patients originating from the United States. We examined five markers spanning ELAVL4 in Norwegian, United States, and Irish PD case-control samples. No association was found between the examined markers and AAO or PD in Norwegian or US samples. However, ELAVL4 markers (rs967582 and rs3902720) were significantly associated with susceptibility to PD in our Irish series. Our data suggest that the association between ELAVL4 and PD previously observed might be explained by a Celtic-founder effect.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Alleles
  • ELAV Proteins / genetics*
  • ELAV-Like Protein 4
  • Female
  • Genetic Linkage / genetics
  • Genetic Markers
  • Genetic Predisposition to Disease
  • Humans
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Male
  • Middle Aged
  • Norway / ethnology
  • Parkinson Disease / ethnology*
  • Parkinson Disease / genetics*
  • Point Mutation / genetics
  • Protein-Serine-Threonine Kinases / genetics
  • Ubiquitin-Protein Ligases / genetics*
  • United States

Substances

  • ELAV Proteins
  • ELAV-Like Protein 4
  • ELAVL4 protein, human
  • Genetic Markers
  • Ubiquitin-Protein Ligases
  • parkin protein
  • LRRK2 protein, human
  • Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
  • Protein-Serine-Threonine Kinases