Depression and anxiety levels in therapy-naive patients with inflammatory bowel disease and cancer of the colon

World J Gastroenterol. 2007 Jan 21;13(3):438-43. doi: 10.3748/wjg.v13.i3.438.


Aim: To assess whether depression and anxiety are more expressed in patients with the first episode of inflammatory bowel disease (IBD) than in individuals with newly discovered cancer of the colon (CCa).

Methods: A total of 32 patients with IBD including 13 males and 19 females, aged 27 to 74, and 30 patients with CCa including 20 males and 10 females, aged 39-78, underwent a structured interview, which comprised Hamilton's Depression Rating Inventory, Hamilton's Anxiety Rating Inventory and Paykel's Stressful Events Rating Scale.

Results: Patients of the IBD group expressed both depression and anxiety. Depressive mood, sense of guilt, psychomotor retardation and somatic anxiety were also more pronounced in IBD patients. The discriminant function analysis revealed the total depressive score was of high importance for the classification of a newly diagnosed patient into one of the groups.

Conclusion: Newly diagnosed patients with IBD have higher levels of depression and anxiety. Moreover, a psychiatrist in the treatment team is advisable from the beginning.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Anxiety / etiology*
  • Case-Control Studies
  • Colonic Neoplasms / psychology*
  • Depression / etiology*
  • Discriminant Analysis
  • Female
  • Humans
  • Inflammatory Bowel Diseases / psychology*
  • Male
  • Middle Aged
  • Pilot Projects
  • Stress, Physiological / etiology