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Review
, 303 (2), 421-33

Why Polyps Regenerate and We Don't: Towards a Cellular and Molecular Framework for Hydra Regeneration

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Review

Why Polyps Regenerate and We Don't: Towards a Cellular and Molecular Framework for Hydra Regeneration

Thomas C G Bosch. Dev Biol.

Abstract

The basis for Hydra's enormous regeneration capacity is the "stem cellness" of its epithelium which continuously undergoes self-renewing mitotic divisions and also has the option to follow differentiation pathways. Now, emerging molecular tools have shed light on the molecular processes controlling these pathways. In this review I discuss how the modular tissue architecture may allow continuous replacement of cells in Hydra. I also describe the discovery and regulation of factors controlling the transition from self-renewing epithelial stem cells to differentiated cells.

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