A severe case of dentatorubro-pallidoluysian atrophy (DRPLA) with microcephaly, very early onset of seizures, and cerebral white matter involvement

Neuropediatrics. 2006 Oct;37(5):308-11. doi: 10.1055/s-2006-955967.


We report a severe case of Dentatorubro-pallidoluysian atrophy (DRPLA) presenting with microcephaly, developmental delay, severe epilepsy, and progressive mental deterioration with a very early onset of disease. The case is notable for the early detection of white matter changes by brain MRI. Neuroradiological findings from the case were compared to those of previously reported patients with disease onset before 10 years of age.

Publication types

  • Case Reports

MeSH terms

  • Child
  • Humans
  • Infant, Newborn
  • Infant, Newborn, Diseases*
  • Longitudinal Studies
  • Magnetic Resonance Imaging / methods
  • Male
  • Microcephaly / complications*
  • Microcephaly / pathology
  • Myoclonic Epilepsies, Progressive / complications*
  • Myoclonic Epilepsies, Progressive / pathology
  • Review Literature as Topic
  • Seizures / etiology*