Abstract
This experiment was designed to determine if intraventricular administration of basic fibroblast growth factor (bFGF) could promote cerebral angiogenesis in a model of mild chronic forebrain ischemia. Wistar rats underwent bilateral carotid artery ligation. Animals received intraventricular injections of bFGF every 4 days for 28 days. Basic fibroblast growth factor caused a significant dose-dependent increase in capillary density compared to ischemic controls in all regions examined. These results support the hypothesis that chronic intraventricular administration of bFGF induces in vivo cerebral angiogenesis.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Blood Pressure / drug effects
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Brain Ischemia / complications*
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Brain Ischemia / pathology
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Capillaries / drug effects
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Carbon Dioxide / blood
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Carotid Arteries / physiology
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Cerebral Cortex / pathology
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Fibroblast Growth Factor 2 / administration & dosage
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Fibroblast Growth Factor 2 / pharmacology*
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Hydrogen-Ion Concentration
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Injections, Intraventricular
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Male
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Neovascularization, Pathologic / chemically induced*
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Neovascularization, Pathologic / complications
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Neovascularization, Pathologic / pathology
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Oxygen / blood
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Rats
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Rats, Inbred Strains
Substances
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Fibroblast Growth Factor 2
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Carbon Dioxide
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Oxygen