T-lymphoblastic lymphoma arising in the small intestine

Pathology. 1991 Oct;23(4):356-9. doi: 10.3109/00313029109063605.


The authors report the clinical, pathological and immunological features of a case of T-lymphoblastic lymphoma presenting with protein-losing enteropathy. There was extensive multifocal involvement of the duodenum, jejunum and ileum. The mediastinum was not enlarged; the peripheral blood picture and bilateral bone marrow trephine biopsies were unremarkable. The tumor cells were positive for terminal deoxynucleotide transferase, CD3, CD2, CD7 and CD10; they were negative for CD1, CD5, CD4, CD8 and HLA-DR. The immunophenotype was that of an immature thymic T-cell. Monocytic and B-cell markers were negative. Despite initial dose reduction in chemotherapy, the patient still developed massive intestinal hemorrhage and succumbed 2 wks after treatment. Postmortem examination confirmed absence of thymic involvement. The overall picture strongly suggests a primary intestinal origin of this T-lymphoblastic lymphoma which contradicts the conventional wisdom that T-lymphoblastic lymphoma arises in the thymus from primitive cortical lymphocytes before rapidly disseminating.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antigens, CD / analysis
  • Antigens, CD7
  • Antigens, Differentiation / analysis
  • Antigens, Differentiation, T-Lymphocyte / analysis
  • Antigens, Neoplasm / analysis
  • CD2 Antigens
  • CD3 Complex
  • Duodenal Neoplasms / immunology
  • Duodenal Neoplasms / pathology*
  • Humans
  • Ileal Neoplasms / immunology
  • Ileal Neoplasms / pathology*
  • Immunophenotyping
  • Jejunal Neoplasms / immunology
  • Jejunal Neoplasms / pathology*
  • Lymphoma, T-Cell / immunology
  • Lymphoma, T-Cell / pathology*
  • Male
  • Neprilysin
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology*
  • Receptors, Antigen, T-Cell / analysis
  • Receptors, Immunologic / analysis


  • Antigens, CD
  • Antigens, CD7
  • Antigens, Differentiation
  • Antigens, Differentiation, T-Lymphocyte
  • Antigens, Neoplasm
  • CD2 Antigens
  • CD3 Complex
  • Receptors, Antigen, T-Cell
  • Receptors, Immunologic
  • Neprilysin