Seizure freedom off antiepileptic drugs after temporal lobe epilepsy surgery

Seizure. 2007 Mar;16(2):95-8. doi: 10.1016/j.seizure.2006.10.007. Epub 2007 Jan 18.


Data are limited on seizure recurrence after antiepileptic drug (AED) discontinuation in operated seizure-free patients. We reviewed seizure outcome in patients who came off AEDs after being seizure-free for 2 years following temporal lobe surgery in our center. Thirty-nine (68%) of 57 patients who discontinued AED therapy remained seizure-free. They had a younger age at surgery than the group with seizure recurrence (p=0.01). Earlier surgery may be a favorable predictor for seizure freedom after AED discontinuation.

MeSH terms

  • Adult
  • Age Factors
  • Anterior Temporal Lobectomy
  • Anticonvulsants / therapeutic use*
  • Drug Administration Schedule
  • Epilepsy, Temporal Lobe / drug therapy
  • Epilepsy, Temporal Lobe / surgery*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Recurrence
  • Remission Induction
  • Treatment Outcome


  • Anticonvulsants