Microglial transplantation increases amyloid-beta clearance in Alzheimer model rats

FEBS Lett. 2007 Feb 6;581(3):475-8. doi: 10.1016/j.febslet.2007.01.009. Epub 2007 Jan 16.


Immunization with amyloid-beta (Abeta) peptides, a therapeutic approach in Alzheimer's disease (AD), reduces brain Abeta, and microglial Abeta phagocytosis has been proposed as an Abeta-lowering mechanism. We transplanted rat microglia into the rat lateral ventricle just after intra-hippocampal Abeta injection, and then investigated the contribution of exogenous microglia to Abeta clearance. Migration of exogenous microglia from the lateral ventricle to Abeta plaque was detected by magnetic resonance imaging and histochemical analysis, and the clearance of Abeta was increased by transplantation. These results suggest the possible usefulness of exogenous microglia to the therapeutic approach in AD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease / metabolism*
  • Alzheimer Disease / pathology
  • Alzheimer Disease / surgery*
  • Amyloid beta-Peptides / metabolism*
  • Animals
  • Brain Tissue Transplantation
  • Cell Movement
  • Disease Models, Animal
  • Hippocampus / metabolism
  • Hippocampus / pathology
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Microglia / physiology
  • Microglia / transplantation*
  • Phagocytosis
  • Rats
  • Rats, Wistar
  • Tumor Necrosis Factor-alpha / metabolism


  • Amyloid beta-Peptides
  • Tumor Necrosis Factor-alpha