Abstract
Substitution of the new diamine antibiotic SQ109 for ethambutol in a mouse model of chronic tuberculosis (TB) improved efficacy of combination drug therapy with first-line TB drugs rifampin and isoniazid, with or without pyrazinamide: at 8 weeks, lung bacteria were 1.5 log10 lower in SQ109-containing regimens.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Adamantane / analogs & derivatives*
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Adamantane / pharmacology
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Adamantane / therapeutic use
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Animal Experimentation
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Animals
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Anti-Bacterial Agents / pharmacology
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Antitubercular Agents / pharmacology*
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Antitubercular Agents / therapeutic use*
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Drug Therapy, Combination*
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Ethylenediamines / pharmacology
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Ethylenediamines / therapeutic use*
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Lung
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Mice
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Mycobacterium tuberculosis / drug effects*
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Treatment Outcome
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Tuberculosis / drug therapy*
Substances
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Anti-Bacterial Agents
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Antitubercular Agents
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Ethylenediamines
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N-geranyl-N'-(2-adamantyl)ethane-1,2-diamine
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Adamantane