Tuberculous cranial pachymeningitis

Neurology. 2007 Jan 23;68(4):298-300. doi: 10.1212/01.wnl.0000252367.99393.34.

Abstract

We describe two immunocompetent patients with tuberculous cranial pachymeningitis. Both patients underwent biopsy after focal dural thickening was identified on MRI. Histopathologic examination of tissue revealed necrotizing granulomatous inflammation. PCR for Mycobacterium tuberculosis DNA was negative on CSF but positive on tissue. Both patients responded to antituberculous therapy. Although uncommon as a cause of cranial pachymeningitis, tuberculosis should be considered, since it responds well to treatment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antitubercular Agents / therapeutic use
  • Dura Mater / diagnostic imaging*
  • Dura Mater / pathology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Radiography
  • Tuberculosis, Meningeal / diagnostic imaging*
  • Tuberculosis, Meningeal / drug therapy
  • Tuberculosis, Meningeal / pathology*

Substances

  • Antitubercular Agents