EBV+ lymphoproliferative disease following prolonged chemotherapy for refractory LCH

Pediatr Blood Cancer. 2008 Mar;50(3):728-30. doi: 10.1002/pbc.21121.

Abstract

Epstein-Barr virus (EBV) is a herpesvirus for which latent infection in B lymphocytes occurs in most individuals by middle childhood. Clinically significant reactivation of this virus occurs in the context of suppressed cell-mediated immunity, occasionally developing into lymphoproliferative disease (EBV-LPD). EBV reactivation is rarely associated with intensive chemotherapy alone. Here we present the case of a 4-year-old female who developed EBV-LPD as a complication of prolonged immunosuppressive chemotherapy for her multiply-recurrent Langerhans cell histiocytosis (LCH).

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Monoclonal / therapeutic use
  • Antibodies, Monoclonal, Murine-Derived
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Asparaginase / administration & dosage
  • Asparaginase / adverse effects
  • Asparaginase / therapeutic use
  • Cytarabine / administration & dosage
  • Cytarabine / adverse effects
  • Cytarabine / therapeutic use
  • Doxorubicin / administration & dosage
  • Drug Therapy, Combination
  • Epstein-Barr Virus Infections / complications*
  • Fatal Outcome
  • Female
  • Herpesvirus 4, Human / physiology
  • Histiocytosis, Langerhans-Cell / complications
  • Histiocytosis, Langerhans-Cell / drug therapy*
  • Histiocytosis, Langerhans-Cell / immunology
  • Humans
  • Immunocompromised Host
  • Infant
  • Lymphoma, Large B-Cell, Diffuse / drug therapy
  • Lymphoma, Large B-Cell, Diffuse / etiology*
  • Lymphoma, Large B-Cell, Diffuse / virology
  • Mercaptopurine / administration & dosage
  • Mercaptopurine / adverse effects
  • Mercaptopurine / therapeutic use
  • Methotrexate / administration & dosage
  • Methotrexate / adverse effects
  • Methotrexate / therapeutic use
  • Mycoses / etiology
  • Prednisone / administration & dosage
  • Prednisone / adverse effects
  • Prednisone / therapeutic use
  • Recurrence
  • Rituximab
  • Vinblastine / administration & dosage
  • Vinblastine / adverse effects
  • Vinblastine / therapeutic use
  • Vincristine / administration & dosage
  • Virus Activation

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Murine-Derived
  • Cytarabine
  • Rituximab
  • Vincristine
  • Vinblastine
  • Doxorubicin
  • Mercaptopurine
  • Asparaginase
  • Prednisone
  • Methotrexate