Relapse rates in an early psychosis treatment service

Acta Psychiatr Scand. 2007 Feb;115(2):126-31. doi: 10.1111/j.1600-0447.2006.00879.x.


To examine the relapse rate achievable in a real-life early psychosis treatment service.

Method: A 2-year longitudinal cohort study of consecutive admissions to an early psychosis programme which served the entire population in a catchment area. The primary outcome measure was relapse.

Results: One hundred and forty-eight consecutive consenting admissions were recruited, 124 (83.8%) of whom were followed for 1 year and 116 (78.4%) for 2 years. Relapse was assessed by clinicians using structured criteria. The 2-year relapse rate among subjects with complete data collection was 34/95 (35.7%, 95% CI 26.2-46.3). A Kaplan-Meier life table censoring subjects lost to follow-up yielded a comparable estimate of the proportion not relapsing: 68% (95% CI 58-76%).

Conclusion: These estimates compare favourably with a published range of 2-year relapse from 55% to 70% in the older literature and are comparable with the results in recent clinical trials.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cohort Studies
  • Demography
  • Diagnostic and Statistical Manual of Mental Disorders
  • Early Diagnosis
  • Female
  • Follow-Up Studies
  • Humans
  • Kaplan-Meier Estimate
  • Male
  • Mental Health Services / statistics & numerical data
  • Middle Aged
  • Patient Admission / statistics & numerical data*
  • Prevalence
  • Program Development / statistics & numerical data*
  • Psychotic Disorders / diagnosis
  • Psychotic Disorders / epidemiology*
  • Psychotic Disorders / therapy*
  • Recurrence