Adult neurogenesis and hippocampal memory function: new cells, more plasticity, new memories?

Neurosurg Clin N Am. 2007 Jan;18(1):105-13, x. doi: 10.1016/


The discovery of active adult neurogenesis in mammals, a process of generating functional neurons from neural stem cells, suggests that the adult brain is more dynamic than once imagined. The coincidence of this phenomenon occurring in the hippocampus, a region critical to the learning process, begs the question of whether adult neurogenesis is involved in memory formation. Here, the authors review rapidly accumulating evidence showing a strong correlation between certain types of memory functions and adult neurogenesis in the hippocampus. Establishment of the potential link between memory formation and adult neurogenesis is instrumental, at a basic science level, to understand the function of neural networks and is essential, at a clinical level, to develop effective therapies for various cognitive dysfunctions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult Stem Cells / cytology*
  • Adult Stem Cells / physiology
  • Animals
  • Cell Division / physiology
  • Hippocampus / cytology*
  • Hippocampus / physiology
  • Humans
  • Learning / physiology
  • Memory / physiology*
  • Neuronal Plasticity / physiology*