A comparison of dermabond tissue adhesive and sutures in the primary repair of the congenital cleft lip

Ann Plast Surg. 2007 Feb;58(2):121-5. doi: 10.1097/01.sap.0000232984.68797.62.


Objective: To compare the long-term cosmesis of Dermabond (octyl-2-cyanoacrylate) and traditional skin sutures among patients undergoing primary cleft lip +/- palate repair.

Materials and methods: Eleven patients underwent photographic analysis following primary cleft lip +/- palate repair, including the use of Dermabond. Eleven age-matched controls who underwent cleft lip +/- palate repair with traditional suture closure served as controls. Cosmesis was assessed by 3 blinded plastic surgeons using a visual analogue scale (VAS) and the Hollander Wound Evaluation Scale (HWES).

Results: The overall mean VAS score for the patients treated with and without Dermabond was 70.0 (SD, 9.5) and 68.3 (SD, 13.4), respectively (P = 0.46). The overall mean HWES score for the patients treated with and without Dermabond was 1.7 (SD 1.7) (P = 0.92).

Conclusions: Dermabond tissue adhesive offers equivalent mature wound cosmesis as traditional suture closure in the repair of the congenital cleft lip +/- palate.

Publication types

  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Child, Preschool
  • Cleft Lip / surgery*
  • Cleft Palate / surgery
  • Cyanoacrylates*
  • Dioxanes*
  • Esthetics*
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Male
  • Pain Measurement
  • Polyesters*
  • Polyglactin 910*
  • Single-Blind Method
  • Sutures*
  • Tissue Adhesives*
  • Treatment Outcome
  • Wound Healing / physiology


  • Cyanoacrylates
  • Dioxanes
  • Polyesters
  • Tissue Adhesives
  • Polyglactin 910
  • glycolide E-caprolactone copolymer
  • octyl 2-cyanoacrylate