Multiple levels of cyclin specificity in cell-cycle control

Nat Rev Mol Cell Biol. 2007 Feb;8(2):149-60. doi: 10.1038/nrm2105.


Cyclins regulate the cell cycle by binding to and activating cyclin-dependent kinases (Cdks). Phosphorylation of specific targets by cyclin-Cdk complexes sets in motion different processes that drive the cell cycle in a timely manner. In budding yeast, a single Cdk is activated by multiple cyclins. The ability of these cyclins to target specific proteins and to initiate different cell-cycle events might, in some cases, reflect the timing of the expression of the cyclins; in others, it might reflect intrinsic properties of the cyclins that render them better suited to target particular proteins.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Cycle*
  • Cyclin-Dependent Kinases / metabolism*
  • Cyclins / genetics
  • Cyclins / physiology*
  • Evolution, Molecular
  • Gene Expression Regulation, Fungal*
  • Phosphorylation
  • Saccharomycetales / metabolism*
  • Saccharomycetales / physiology
  • Signal Transduction


  • Cyclins
  • Cyclin-Dependent Kinases