Corneal endothelial cell density and morphology in healthy Chinese eyes

Cornea. 2007 Feb;26(2):130-2. doi: 10.1097/ICO.0b013e31802be63e.

Abstract

Purpose: To describe corneal endothelial cell density and morphology in healthy Chinese eyes.

Methods: Specular microscopy was performed in 1329 eyes of 700 healthy volunteers (M:F, 311:389), 10 to 98 years of age. Parameters studied included endothelial cell density (CD), cell area (CA), coefficient of variation (CV) in cell area, and percent hexagonality.

Results: Mean endothelial CD in the study population was 2932 +/- 363 cells/mm2. There was a statistically significant decrease in endothelial CD (P < 0.001; correlation, -0.435) and percentage of hexagonal cells (P < 0.001; correlation, -0.241) with age. Mean CA, CV, and percentage of hexagonal cells were 347 +/- 46 microm2, 33 +/- 5, and 59% +/- 9%, respectively. There was also a statistically significant increase in CA (P < 0.001; correlation, 0.410) and CV (P < 0.001; correlation, 0.251) with increasing age.

Conclusions: Normative data for the endothelium in the Chinese population are reported. Our data add to the knowledge about endothelial cell parameters in Chinese eyes and serve as a baseline for comparative studies with other populations.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Asian Continental Ancestry Group*
  • Cell Count
  • Child
  • Endothelium, Corneal / cytology*
  • Female
  • Hong Kong
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Reference Values
  • Sex Distribution
  • Sex Factors