Suppressive effect of partially hydrolyzed guar gum on transitory diarrhea induced by ingestion of maltitol and lactitol in healthy humans

Eur J Clin Nutr. 2007 Sep;61(9):1086-93. doi: 10.1038/sj.ejcn.1602623. Epub 2007 Jan 24.

Abstract

Objectives: To estimate the suppressive effect of partially hydrolyzed guar gum (PHGG) on transitory diarrhea induced by ingestion of a sufficient amount of maltitol or lactitol in female subjects.

Design: The first, the minimal dose level of maltitol and lactitol that would induce transitory diarrhea was estimated separately for each subject. Individual subject was administered a dose that increased by 5 g stepwise from 10 to 45 g until diarrhea was experienced. Thereafter, the suppressive effect on diarrhea was observed after each subject ingested a mixture of 5 g of PHGG and the minimal dose level of maltitol or lactitol.

Setting: Laboratory of Public Health Nutrition, Department of Nutrition and Health Sciences, Siebold University of Nagasaki.

Subjects: Thirty-four normal female subjects (21.3+/-0.9 years; 49.5+/-5.3 kg).

Main outcome measurement: Incidence of diarrhea caused by the ingestion of maltitol or lactitol and the ratio of suppression achieved by adding PHGG for diarrhea.

Results: The ingestion of amounts up to 45 g of maltitol, diarrhea caused in 29 of 34 subjects (85.3%), whereas the ingestion of lactitol caused diarrhea in 100%. The diarrhea owing to maltitol was improved in 10 of 28 subjects by the addition of 5 g of PHGG to minimal dose-induced diarrhea, and that owing to lactitol was in seven of 19 subjects. Adding 10 g of PHGG strongly suppressed the diarrhea caused by maltitol, and the cumulative ratio was 82.1% (23/28).

Conclusion: The transitory diarrhea caused by the ingestion of maltitol or lactitol was clearly suppressed by the addition of PHGG. These results strongly suggest that diarrhea caused by the ingestion of a sufficient amount of non-digestible sugar substitute can be suppressed by the addition of dietary fiber.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Cathartics / administration & dosage
  • Cathartics / adverse effects*
  • Diarrhea / chemically induced
  • Diarrhea / drug therapy*
  • Dietary Fiber / therapeutic use*
  • Dose-Response Relationship, Drug
  • Female
  • Galactans / therapeutic use*
  • Gastrointestinal Motility / drug effects*
  • Humans
  • Maltose / administration & dosage
  • Maltose / adverse effects
  • Maltose / analogs & derivatives
  • Mannans / therapeutic use*
  • Plant Gums / therapeutic use*
  • Sugar Alcohols / administration & dosage
  • Sugar Alcohols / adverse effects
  • Treatment Outcome

Substances

  • Cathartics
  • Dietary Fiber
  • Galactans
  • Mannans
  • Plant Gums
  • Sugar Alcohols
  • Maltose
  • maltitol
  • guar gum
  • lactitol