Abstract
The addition of a ligand molecule to an artificial self-assembled triple helix leads to the selective intercalation of two hydrogen-bonded trimers in specific binding pockets. Furthermore, the triple helix suffers large conformational rearrangements in order to accommodate the ligand molecules in a highly organized manner.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Binding Sites
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Cell Physiological Phenomena
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DNA / chemistry*
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Hydrogen Bonding
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Intercalating Agents / chemistry*
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Ligands
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Magnetic Resonance Spectroscopy
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Molecular Mimicry
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Nucleic Acid Conformation
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Proteins / chemistry
Substances
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Intercalating Agents
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Ligands
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Proteins
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DNA