Further investigation into the natural product chemistry of the tropical marine sponge Agelas oroides has yielded the new compound 2,4,6,6-tetramethyl-3(6 H)-pyridone (1), and 2,2,6,6-tetramethyl-4-piperidone (2). Both compounds are volatile. The structures of 1 and 2 were determined from the interpretation of their 1D and 2D NMR, UV, IR, and mass spectral data.