Antioxidants and CVD in diabetes: where do we stand now

Curr Diab Rep. 2007 Feb;7(1):8-13. doi: 10.1007/s11892-007-0003-9.


Diabetes is an oxidative stress disorder as a result of both hyperglycemia and increased levels of free fatty acids. Oxidative stress has been implicated in the pathogenesis of diabetes-related complications, and treatment with antioxidants seemed to be a promising therapeutic option. Although animal studies and preliminary human studies were initially encouraging, subsequent human studies have failed to show a clear benefit of antioxidants, whereas some studies have even suggested that they can be potentially harmful. Therefore, treatment with antioxidants cannot be currently recommended as a therapeutic option.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Antioxidants / adverse effects
  • Antioxidants / pharmacology*
  • Antioxidants / therapeutic use
  • Cardiovascular Diseases / complications*
  • Cardiovascular Diseases / drug therapy
  • Cardiovascular Diseases / metabolism*
  • Diabetes Mellitus / drug therapy*
  • Diabetes Mellitus / metabolism*
  • Diet
  • Endothelium / drug effects
  • Endothelium / metabolism
  • Endothelium / physiopathology
  • Humans
  • Oxidative Stress


  • Antioxidants