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Multicenter Study
, 33 (3), 665-72

North American Prodrome Longitudinal Study: A Collaborative Multisite Approach to Prodromal Schizophrenia Research

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Multicenter Study

North American Prodrome Longitudinal Study: A Collaborative Multisite Approach to Prodromal Schizophrenia Research

Jean Addington et al. Schizophr Bull.

Abstract

This article presents the rationale, design, and preliminary findings of the North American Prodrome Longitudinal Study (NAPLS), a collaborative, multisite investigation into the earliest phase of psychotic illness. We describe how 8 independently conceived research projects were integrated methodologically, how diagnostic reliability was achieved across sites on the Structured Interview for Prodromal Syndromes, and how baseline and follow-up data were aggregated for 888 at risk and comparison subjects. Data are presented describing the demographic, academic/work, and diagnostic characteristics of 3 relevant subgroups: persons at heightened clinical risk for psychosis, help-seeking comparison subjects, and nonpsychiatric controls. The NAPLS data set will be used to explore a series of questions related to prodromal psychosis, including the descriptive phenomenology of currently accepted diagnostic criteria, conversion rates over a 30-month period, predictors of psychosis onset and functional disability, and the impact of early treatment on the course of prodromal symptoms.

Figures

Fig. 1.
Fig. 1.
Number of peer-reviewed articles published on the prodrome to psychosis, 1976–2005.

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