Nibbling within the nucleus: turnover of nuclear contents

Cell Mol Life Sci. 2007 Mar;64(5):581-8. doi: 10.1007/s00018-007-6395-5.


As the site of gene expression and regulation, the nucleus is the control center of the cell. It might be thought that degradation of nuclear contents is strictly 'off-limits,' given the importance of the genetic information contained within the nucleus, but it has recently been reported that partial degradation of the nucleus may occur in yeast. Here we summarize the evidence for the degradation and quality control of proteins found with the nucleus and its compartments, and of nucleic acids that may occur under certain specific conditions. Only under certain special conditions such as differentiation of the lens are the entire nuclear contents degraded.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Autophagy
  • Cell Nucleolus / physiology
  • Cell Nucleus / genetics
  • Cell Nucleus / physiology*
  • Cell Physiological Phenomena
  • Coiled Bodies / physiology
  • DNA / metabolism
  • Gene Expression Regulation*
  • Genetic Diseases, Inborn / genetics
  • Humans
  • Nuclear Proteins / metabolism
  • Organelles / physiology


  • Nuclear Proteins
  • DNA