RK-95113, a new angiogenesis inhibitor produced by Aspergillus fumigatus

J Antibiot (Tokyo). 2006 Nov;59(11):724-8. doi: 10.1038/ja.2006.97.

Abstract

We found that the strain Aspergillus fumigatus var. fumigatus RK95-113 produced a new angiogenesis inhibitor, RK-95113. Spectroscopic analyses identified the structure of RK-95113 as a new fumagillin-related small molecule. RK-95113 preferentially inhibited the growth of human umbilical vein endothelial cells (HUVECs) rather than that of human normal fibroblasts in cell proliferation assays and blocked endothlial cell migration induced by vascular endothelial growth factor (VEGF).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiogenesis Inhibitors / chemistry*
  • Angiogenesis Inhibitors / isolation & purification
  • Angiogenesis Inhibitors / pharmacology
  • Aspergillus fumigatus / chemistry
  • Aspergillus fumigatus / metabolism
  • Cell Growth Processes / drug effects
  • Cell Movement / drug effects
  • Endothelial Cells / cytology
  • Endothelial Cells / drug effects
  • Epoxy Compounds / chemistry*
  • Epoxy Compounds / isolation & purification
  • Epoxy Compounds / pharmacology
  • Fermentation
  • Fibroblasts / cytology
  • Fibroblasts / drug effects
  • Humans
  • Nuclear Magnetic Resonance, Biomolecular
  • Sesquiterpenes / chemistry*
  • Sesquiterpenes / isolation & purification
  • Sesquiterpenes / pharmacology

Substances

  • Angiogenesis Inhibitors
  • Epoxy Compounds
  • RK-95113
  • Sesquiterpenes