Pathological diagnosis of granulomatous lung disease: a review

Histopathology. 2007 Feb;50(3):289-310. doi: 10.1111/j.1365-2559.2006.02546.x.


Granulomas in the lung are common diagnostic problems encountered by pathologists. They occur in a wide range of pulmonary conditions, ranging from common entities to uncommon ones and including both infections and non-infectious diseases. This review summarizes the main histological features that help distinguish various granulomatous lung diseases. It concentrates on the most important and common entities that may be encountered and emphasizes helpful features in the differential diagnosis.

Publication types

  • Review

MeSH terms

  • Diagnosis, Differential
  • Granuloma, Respiratory Tract / microbiology
  • Granuloma, Respiratory Tract / pathology*
  • Granulomatosis with Polyangiitis / diagnosis
  • Humans
  • Lung Diseases / classification
  • Lung Diseases / pathology*
  • Sarcoidosis / diagnosis
  • Tuberculosis, Pulmonary / diagnosis