Are statins associated with decreased tooth loss in chronic periodontitis?

J Clin Periodontol. 2007 Mar;34(3):214-9. doi: 10.1111/j.1600-051X.2006.01046.x. Epub 2007 Jan 25.

Abstract

Aim: To evaluate whether statin use was associated with decreased tooth loss among patients with chronic periodontitis.

Material and methods: We evaluated administrative health plan data from 1996 to 2002 covering dental and periodontal treatment utilization, dental extractions, and prescription medication fills of 12,631 adults aged 48-64 in 2002. With tooth loss as the outcome, we evaluated a number of different patterns of statin prescription across time in multivariate generalized linear models.

Results: Unadjusted, statin use was associated with increased tooth loss. After adjustment for potential confounders, there was no suggestion of either increased or decreased tooth loss associated with statin use.

Conclusions: Statin use was not associated with either a decreased or an increased risk of tooth loss.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Anticholesteremic Agents / therapeutic use*
  • Chronic Disease
  • Dental Care / statistics & numerical data
  • Epidemiologic Methods
  • Female
  • Humans
  • Male
  • Middle Aged
  • Periodontitis / complications*
  • Periodontitis / diagnosis
  • Smoking
  • Tooth Loss / diagnosis
  • Tooth Loss / etiology
  • Tooth Loss / prevention & control*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Anticholesteremic Agents