Anti-VEGF bevacizumab (Avastin) for radiation optic neuropathy

Am J Ophthalmol. 2007 Feb;143(2):335-8. doi: 10.1016/j.ajo.2006.09.014. Epub 2006 Oct 23.


Purpose: To evaluate intravitreal bevacizumab treatment for radiation optic neuropathy (RON).

Design: Interventional case report.

Methods: At The New York Eye Cancer Center, a patient symptomatic of decreased vision because of RON was treated with intravitreal bevacizumab (1.25 mg). Main outcome measures included visual acuity, appearance of the optic nerve, fundus photography, angiography, and optical coherence tomography/scanning laser ophthalmoscopy (OCT/SLO).

Results: Within one week, her vision improved from 20/32 to 20/20 with a reduction in optic disk hemorrhage. At six weeks, evidence of both decreased hemorrhage and optic disk edema was documented by photography, angiography, and OCT/SLO. At the three and five-month follow-up visits, the hemorrhages resolved, and her disk margins were sharp. There were no ocular or systemic side effects.

Conclusions: Intravitreal bevacizumab was tolerated, improved vision, and reduced hemorrhage as well as optic disk edema (angiographic leakage). Anti-VEGF therapy (e.g. bevacizumab) should be investigated for both ocular and nonocular radiation neuropathy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Angiogenesis Inhibitors / therapeutic use*
  • Antibodies, Monoclonal / therapeutic use*
  • Antibodies, Monoclonal, Humanized
  • Bevacizumab
  • Brachytherapy / adverse effects
  • Choroid Neoplasms / radiotherapy
  • Female
  • Fluorescein Angiography
  • Humans
  • Injections
  • Melanoma / radiotherapy
  • Ophthalmoscopy
  • Optic Disk / radiation effects*
  • Optic Nerve Diseases / diagnosis
  • Optic Nerve Diseases / drug therapy*
  • Optic Nerve Diseases / etiology
  • Radiation Injuries / diagnosis
  • Radiation Injuries / drug therapy*
  • Radiation Injuries / etiology
  • Tomography, Optical Coherence
  • Vascular Endothelial Growth Factor A / antagonists & inhibitors*
  • Visual Acuity
  • Vitreous Body


  • Angiogenesis Inhibitors
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A
  • Bevacizumab