Strong association between HLA-A*0206 and Stevens-Johnson syndrome in the Japanese

Am J Ophthalmol. 2007 Feb;143(2):367-8. doi: 10.1016/j.ajo.2006.09.029. Epub 2006 Oct 25.


Purpose: To investigate the association between HLA class I antigens and Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) with ocular complications in Japanese.

Design: Case-control study.

Methods: We examined the histocompatibility antigen genes HLA-A, -B, and -C of 40 Japanese SJS/TEN patients with ocular complications and 113 healthy Japanese volunteers by polymerase chain reaction amplification and subsequent hybridization with sequence-specific oligonucleotide probes (PCR-SSO).

Results: We clarified that HLA-A*0206 is strongly associated with SJS/TEN with ocular complications in the Japanese.

Conclusions: Because this finding is completely different from data reported elsewhere on Taiwanese Han Chinese patients and Caucasian patients, it suggests strong ethnic differences in the HLA-SJS association and points to the need for studies in other ethnic populations in order to obtain a global picture.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian People / ethnology
  • Case-Control Studies
  • Conjunctivitis / ethnology
  • Conjunctivitis / genetics*
  • Gene Amplification
  • Gene Frequency
  • Genotype
  • HLA-A Antigens / genetics*
  • HLA-A2 Antigen
  • Humans
  • In Situ Hybridization
  • Japan / epidemiology
  • Oligonucleotide Probes
  • Polymerase Chain Reaction
  • Stevens-Johnson Syndrome / ethnology
  • Stevens-Johnson Syndrome / genetics*


  • HLA-A Antigens
  • HLA-A*02:61 antigen
  • HLA-A2 Antigen
  • Oligonucleotide Probes