This study determined the efficacy of high-resolution ultrasound and color power Doppler as a monitoring tool in the healing of periapical lesions. Five patients with a periapical lesion in the maxillary anterior teeth were chosen for this study. A preoperative ultrasound with color power Doppler was done to analyze the features of the periapical lesion. These patients were then treated by nonsurgical endodontics and followed up on a regular basis. A 6-month postoperative ultrasound and Doppler study of the same lesion was done to observe the healing of the lesion compared with the preoperative images. The ultrasound with Doppler gave inferences of bone healing in all the lesions. This study demonstrates the application of ultrasound and color power Doppler as a viable and nonhazardous tool for monitoring the healing of periapical lesions.