Familial dysphagia and eosinophilia

Gastrointest Endosc. 2007 Feb;65(2):330-4. doi: 10.1016/j.gie.2006.07.021.


Background: Recent reports suggest a familial predisposition to eosinophilic esophagitis (EE) and a link between Schatzki's rings and EE.

Objective: Our objective is to present our experience with 7 families with dysphagia and eosinophilia.

Design: Case series.

Setting: One-thousand-bed community-based teaching hospital.

Patients: Seventeen patients from 7 families with dysphagia and eosinophilia.

Methods: Direct clinical and endoscopic examination with review of radiologic and pathologic data.

Results: Twelve patients had EE alone, one had eosinophilic gastroenteritis (EG) alone, one had EE and EG, and 3 geriatric patients had Schatzki's rings (one with EG and peripheral eosinophilia [PE] and one with PE). EE spanned 2 generations in 4 families and involved 2 brothers in one family.

Limitations: This was a case series.

Conclusion: We propose a familial dysphagia syndrome characterized by eosinophilia in the form of EE, EG, or PE and Schatzki's rings in older generations.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Aged, 80 and over
  • Aphasia / genetics*
  • Child
  • Child, Preschool
  • Eosinophilia / complications*
  • Eosinophilia / genetics
  • Esophagitis / complications*
  • Esophagitis / genetics
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Infant, Newborn
  • Male
  • Middle Aged
  • Syndrome