Humanized mice in translational biomedical research

Nat Rev Immunol. 2007 Feb;7(2):118-30. doi: 10.1038/nri2017.


The culmination of decades of research on humanized mice is leading to advances in our understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity, infectious diseases, cancer biology and regenerative medicine. In this Review, we discuss the development of these new generations of humanized mice, how they will facilitate translational research in several biomedical disciplines and approaches to overcome the remaining limitations of these models.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Chimera / genetics
  • Chimera / immunology*
  • Communicable Diseases / immunology
  • Disease Models, Animal
  • Hematopoiesis / immunology
  • Humans
  • Mice
  • Mice, Knockout / genetics
  • Mice, Knockout / immunology*
  • Mice, SCID / genetics
  • Mice, SCID / immunology*
  • Mice, Transgenic / genetics
  • Mice, Transgenic / immunology*
  • Neoplasms / immunology