Regulation of T-cell activation by the cytoskeleton

Nat Rev Immunol. 2007 Feb;7(2):131-43. doi: 10.1038/nri2021.


To become activated, T cells must efficiently recognize antigen-presenting cells or target cells through several complex cytoskeleton-dependent processes, including integrin-mediated adhesion, immunological-synapse formation, cellular polarization, receptor sequestration and signalling. The actin and microtubule systems provide the dynamic cellular framework that is required to orchestrate these processes and ultimately contol T-cell activation. Here, we discuss recent advances that have furthered our understanding of the crucial importance of the T-cell cytoskeleton in controlling these aspects of T-cell immune recognition.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology
  • Cytoskeleton / immunology*
  • Humans
  • Lymphocyte Activation / immunology*
  • Mice
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology*