The structures of two new ENT-kaurane diterpenoids and two derivatives of shikokianin isolated from leaves of Isodon leucophyllus were elucidated by 1D and 2D NMR techniques as 11alpha-acetoxyeffusanin D, 6-acetylepinodosinol, 16beta-ethoxymethyleneshikokianin, and 16alpha-ethoxymethyleneshi-kokianin.