RNA editing

Curr Opin Cell Biol. 1991 Dec;3(6):1056-61. doi: 10.1016/0955-0674(91)90129-m.

Abstract

Since its discovery, RNA editing in kinetoplastid mitochondria has proven a fascinating topic of study, and the last one and a half years have witnessed enormous advances in our understanding of this unprecedented form of RNA processing. The information flow in this RNA editing, once considered a candidate for defying the central dogma, is now known to conform to the DNA-to-RNA-to-protein paradigm, with the novel feature that the sequence of an edited region is not actually present in any DNA segment, but instead derives by a novel micro-interdigitating of information encoded in multiple DNA regions.

Publication types

  • Review

MeSH terms

  • Mitochondria / metabolism*
  • Models, Genetic
  • RNA / genetics
  • RNA / metabolism*
  • RNA Processing, Post-Transcriptional*

Substances

  • RNA