A checklist for medication compliance and persistence studies using retrospective databases

Value Health. 2007 Jan-Feb;10(1):3-12. doi: 10.1111/j.1524-4733.2006.00139.x.


The increasing number of retrospective database studies related to medication compliance and persistence (C&P), and the inherent variability within each, has created a need for improvement in the quality and consistency of medication C&P research. This article stems from the International Society of Pharmacoeconomics and Outcomes Research (ISPOR) efforts to develop a checklist of items that should be either included, or at least considered, when a retrospective database analysis of medication compliance or persistence is undertaken. This consensus document outlines a systematic approach to designing or reviewing retrospective database studies of medication C&P. Included in this article are discussions on data sources, measures of C&P, results reporting, and even conflict of interests. If followed, this checklist should improve the consistency and quality of C&P analyses, which in turn will help providers and payers understand the impact of C&P on health outcomes.

MeSH terms

  • Databases, Bibliographic / standards*
  • Drug Therapy*
  • Guidelines as Topic
  • Humans
  • International Agencies
  • Patient Compliance*
  • Research Design
  • Retrospective Studies*
  • Societies, Pharmaceutical
  • United States