Unsolved mysteries in membrane traffic

Annu Rev Biochem. 2007;76:629-45. doi: 10.1146/annurev.biochem.76.061705.130002.

Abstract

Remarkable strides have been made over the past 20 years in elucidating the molecular basis of membrane trafficking. Indeed, a combination of biochemical and genetic approaches have determined the identity and function of many of the core constituents needed for protein secretion and endocytosis. But much remains to be learned. This review highlights underlying themes in membrane traffic to help us refocus and solve many remaining and newly emerging issues that are fundamental to mammalian cell biology and human physiology.

Publication types

  • Review

MeSH terms

  • ADP-Ribosylation Factors / metabolism
  • Animals
  • Biological Transport / physiology
  • Cell Membrane / chemistry
  • Cell Membrane / metabolism*
  • Cytoplasmic Vesicles / metabolism
  • Endocytosis / physiology*
  • Exocytosis / physiology*
  • Golgi Apparatus / chemistry
  • Golgi Apparatus / metabolism*
  • Humans
  • Membrane Proteins / metabolism
  • Receptors, Peptide / genetics
  • Receptors, Peptide / metabolism
  • SNARE Proteins / metabolism
  • rab GTP-Binding Proteins / metabolism

Substances

  • KDEL receptor
  • Membrane Proteins
  • Receptors, Peptide
  • SNARE Proteins
  • ADP-ribosylation factor related proteins
  • ADP-Ribosylation Factors
  • rab GTP-Binding Proteins