The regulation of complement on cell surfaces

Transfus Med Rev. 1991 Apr;5(2):123-31. doi: 10.1016/s0887-7963(91)70199-5.

Abstract

The regulation of complement at the surface of cells is mediated by both plasma and membrane proteins. These molecules act in concert to prevent the accelerated catabolism of complement proteins and the concomitant lysis of homologous blood cells. The deficiency of either a plasma or membrane protein predisposes to the development of disease.

Publication types

  • Review

MeSH terms

  • Angioedema / genetics
  • Antigens, CD / metabolism
  • CD55 Antigens
  • Complement Activation
  • Complement System Proteins / metabolism*
  • Enzyme Precursors / metabolism
  • Erythrocyte Membrane / metabolism*
  • Hemoglobinuria, Paroxysmal / epidemiology
  • Hemoglobinuria, Paroxysmal / genetics
  • Humans
  • Membrane Cofactor Protein
  • Membrane Glycoproteins / metabolism
  • Membrane Proteins / metabolism
  • Prevalence
  • Receptors, Complement / metabolism
  • Serpins / metabolism

Substances

  • Antigens, CD
  • CD46 protein, human
  • CD55 Antigens
  • Enzyme Precursors
  • Membrane Cofactor Protein
  • Membrane Glycoproteins
  • Membrane Proteins
  • Receptors, Complement
  • Serpins
  • Complement System Proteins