Ultra-high speed and ultra-high resolution spectral-domain optical coherence tomography and optical Doppler tomography in ophthalmology

Bull Soc Belge Ophtalmol. 2006;(302):123-32.


We present ultra-high resolution optical coherence tomography (OCT) structural intensity and optical Doppler tomography (ODT) flow velocity images of the human retina in vivo. The ultra-high speed OCT system is based on Spectral Domain or Fourier Domain technology, which provides a sensitivity advantage over conventional OCT of more than 2 orders of magnitude. This sensitivity improvement allows video rate OCT and ODT cross sectional imaging of retinal structures. Images will be presented with axial resolutions of 6 and 3.5 microns. We observed small features in the inner and outer plexiform layers, which are believed to be small blood vessels. Flow velocity images will be presented showing pulsatile flow in retinal arteries and veins.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Diagnostic Imaging / instrumentation
  • Diagnostic Imaging / methods
  • Diagnostic Techniques, Ophthalmological / instrumentation*
  • Humans
  • Laser-Doppler Flowmetry
  • Optic Disk / anatomy & histology
  • Optic Disk / cytology
  • Reference Values
  • Regional Blood Flow
  • Retinal Vessels / anatomy & histology*
  • Tomography, Optical Coherence / instrumentation*
  • Tomography, Optical Coherence / methods*